Please use this identifier to cite or link to this item:
https://ri.ufs.br/jspui/handle/riufs/591
Document Type: | Artigo |
Title: | Citral reduces nociceptive and inflammatory response in rodents |
Authors: | Quintans-Júnior, Lucindo José Guimarães, Adriana Gibara Santana, Marília Trindade de Araújo, Bruno Eduardo Silva de Moreira, Flávia Viana Bonjardim, Leonardo Rigoldi Araújo, Adriano Antunes de Souza Quintans, Jullyana de Souza Siqueira Antoniolli, Ângelo Roberto Soares, Marco Antonio Botelho Almeida, Jackson Roberto Guedes da Silva Santos, Márcio Roberto Viana dos |
Issue Date: | Jun-2011 |
Abstract: | Citral (CIT), which contains the chiral enantiomers, neral (cis) and geranial (trans), is the majority monoterpene from Lippia alba and Cymbopogon citratus. The present study aimed to evaluate CIT for antinociceptive and anti-inflammatory activities in rodents. Antinociceptive and anti-inflammatory effects were studied by measuring nociception through acetic acid and formalin tests, while inflammation was verified by inducing peritonitis and paw edema with carrageenan. All tested doses of CIT had significant protection (p<0.001) against acetic acid (0.8%) induced nociceptive behavior and the effects were also similar to morphine while formalin induced nociception was significantly protected (p<0.05) only at higher dose (200 mg/kg) of CIT in the first phase of the test. CIT significantly reduce (p<0.001) nociceptive behavior emanating from inflammation in second phase at all the doses.The pretreatment with CIT (100 and 200 mg/kg) significantly reduced the paw edema induced by carrageenan. Moreover, systemic treatment with CIT (100 and 200 mg/kg) significantly reduced (p<0.001) the leukocyte migration in the carrageenan-induced migration to the peritoneal cavity. Our investigation shows that CIT possess significant central and peripheral antinociceptive effects. It was also verified an anti-inflammatory activity. All together these results suggest that CIT might represent important tool for treatment of painful conditions. |
Keywords: | Monoterpenos Citral Anti-inflamatório Atividade antinociceptiva |
ISSN: | 0102-695X |
Citation: | QUINTANS-JUNIOR, L. J. et al. Citral reduces nociceptive and inflammatory response in rodents. Revista Brasileira de Farmacognosia, Curitiba, v. 21, n. 3, jun. 2011. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000300023&lng=en&nrm=iso>. Acesso em: 7 jun. 2013. |
License: | Creative Commons Attribution License |
URI: | https://ri.ufs.br/handle/riufs/591 |
Appears in Collections: | DESL - Artigos de periódicos DFA - Artigos de periódicos DFS - Artigos de periódicos |
Files in This Item:
File | Description | Size | Format | |
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CitralInflammatoryRodents.pdf | 785,51 kB | Adobe PDF | ![]() View/Open |
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