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Document Type: Artigo
Title: Citral reduces nociceptive and inflammatory response in rodents
Authors: Quintans-Júnior, Lucindo José
Guimarães, Adriana Gibara
Santana, Marília Trindade de
Araújo, Bruno Eduardo Silva de
Moreira, Flávia Viana
Bonjardim, Leonardo Rigoldi
Araújo, Adriano Antunes de Souza
Quintans, Jullyana de Souza Siqueira
Antoniolli, Ângelo Roberto
Soares, Marco Antonio Botelho
Almeida, Jackson Roberto Guedes da Silva
Santos, Márcio Roberto Viana dos
Issue Date: Jun-2011
Abstract: Citral (CIT), which contains the chiral enantiomers, neral (cis) and geranial (trans), is the majority monoterpene from Lippia alba and Cymbopogon citratus. The present study aimed to evaluate CIT for antinociceptive and anti-inflammatory activities in rodents. Antinociceptive and anti-inflammatory effects were studied by measuring nociception through acetic acid and formalin tests, while inflammation was verified by inducing peritonitis and paw edema with carrageenan. All tested doses of CIT had significant protection (p<0.001) against acetic acid (0.8%) induced nociceptive behavior and the effects were also similar to morphine while formalin induced nociception was significantly protected (p<0.05) only at higher dose (200 mg/kg) of CIT in the first phase of the test. CIT significantly reduce (p<0.001) nociceptive behavior emanating from inflammation in second phase at all the doses.The pretreatment with CIT (100 and 200 mg/kg) significantly reduced the paw edema induced by carrageenan. Moreover, systemic treatment with CIT (100 and 200 mg/kg) significantly reduced (p<0.001) the leukocyte migration in the carrageenan-induced migration to the peritoneal cavity. Our investigation shows that CIT possess significant central and peripheral antinociceptive effects. It was also verified an anti-inflammatory activity. All together these results suggest that CIT might represent important tool for treatment of painful conditions.
Keywords: Monoterpenos
Atividade antinociceptiva
ISSN: 0102-695X
Citation: QUINTANS-JUNIOR, L. J. et al. Citral reduces nociceptive and inflammatory response in rodents. Revista Brasileira de Farmacognosia, Curitiba, v. 21, n. 3, jun. 2011. Disponível em: <>. Acesso em: 7 jun. 2013.
License: Creative Commons Attribution License
Appears in Collections:DESL - Artigos publicados em periódicos
DFA - Artigos publicados em periódicos
DFS - Artigos publicados em periódicos

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