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Document Type: Artigo
Title: Morinda citrifolia linn leaf extract possesses antioxidant activities and reduces nociceptive behavior and leukocyte migration
Authors: Serafini, Mairim Russo
Santos, Rodrigo Correia
Guimarães, Adriana Gibara
Santos, João Paulo Almeida dos
Santos, Alan Diego da Conceição
Alves, Izabel Almeida
Gelain, Daniel Pens
Nogueira, Paulo Cesar de Lima
Quintans-Júnior, Lucindo José
Bonjardim, Leonardo Rigoldi
Araújo, Adriano Antunes de Souza
Issue Date: Oct-2011
Abstract: Herbal drugs have been used since ancient times to treat a wide range of diseases. Morinda citrifolia Linn (popularly known as ‘‘Noni’’) has been used in folk medicine by Polynesians for over 2,000 years. It is reported to have a broad range of therapeutic effects, including effects against headache, fever, arthritis, gingivitis, respiratory disorders, infections, tuberculosis, and diabetes. The aim of this study was to investigate the antioxidant, anti-inflammatory, antinociceptive, and antibacterial properties of the aqueous extract from M. citrifolia leaves (AEMC). Antioxidant activity was observed against lipid peroxidation, nitric oxide, and hydroxyl radicals. The antinociceptive effect of AEMC was observed in the acetic acid–induced writhing test at the higher dose. Moreover, AEMC significantly reduced the leukocyte migration in doses of 200 and 400 mg/kg and showed mild antibacterial activity. Together, the results suggest that properties of M. citrifolia leaf extract should be explored further in order to achieve newer tools for managing painful and inflammation conditions, including those related to oxidant states.
Keywords: Anti-inflamatório
Atividade antinociceptiva
Atividade antioxidante
Morinda citrifolia
ISSN: 1557-7600
Publisher / Institution : Mary Ann Liebert, Inc.
Citation: SERAFINI, M. R. et al. Morinda citrifolia linn leaf extract possesses antioxidant activities and reduces nociceptive behavior and leukocyte migration. Journal of Medicinal Food, San Diego, v. 14, n. 10, out. 2011. Disponível em: <>. Acesso em: 7 jun. 2013.
License: Copyright Mary Ann Liebert, Inc.
Appears in Collections:DESL - Artigos de periódicos
DFA - Artigos de periódicos

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