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Document Type: Artigo
Title: Anti-inflammatory and redox-protective activities of citronellal
Authors: Melo, Mônica Santos de
Guimarães, Adriana Gibara
Santana, Michele Fraga de
Barreto, Rosana de Souza Siqueira
Lima, Amanda do Carmo Bion de
Dias, Antônio Santos
Santos, Márcio Roberto Viana dos
Onofre, Alexandre Sherlley Casimiro
Quintans, Jullyana de Souza Siqueira
Sousa, Damião Pergentino de
Almeida, Jackson Roberto Guedes da Silva
Estevam, Charles dos Santos
Araujo, Brancilene Santos de
Quintans-Júnior, Lucindo José
Issue Date: Dec-2011
Abstract: The anti-inflammatory and redox protective effects of the citronellal (CT) were evaluated using in vivo and in vitro tests. Intraperitoneal (i.p.) administration of CT (50, 100, and 200 mg/kg) inhibited (p < 0.05) the carrageenan-induced leukocyte migration to the peritoneal cavity. Additionally, the carrageenan- and arachidonic acid-induced rat hind paw edema was significantly inhibited (p < 0.05) by i.p. administration of 100 and 200 mg/kg of the compound. When the redox activity was evaluated, CT (200 mg/kg) significantly reduced hepatic lipoperoxidation (p < 0.001), as well as oxidation of plasmatic (p < 0.05) and hepatic (p < 0.01) proteins. The results of the present study support the hypothesis that CT possesses anti-inflammatory and redox protective activities. It is suggested that its effects are associated with the inhibition of the enzymes in the arachidonic acid pathway, which prevent cell migration by inhibiting leukotriene production, edema formation and the increase of reactive oxygen species in tissues. Therefore, CT is of potential benefit to manage inflammatory disorders and correlated damages caused by oxidant agents.
Keywords: Monoterpenos
ISSN: 0716-9760
Publisher / Institution : Sociedad de Biología de Chile
Citation: MELO, M. S. et al. Anti-inflammatory and redox-protective activities of citronellal. Biological Research, Santiago, v. 44, n. 4, p. 363-368, 2011. Disponível em: <>. Acesso em: 17 jul. 2013.
License: © 2013 Sociedad de Biología de Chile
Appears in Collections:DESL - Artigos publicados em periódicos
DFS - Artigos publicados em periódicos

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