Use este identificador para citar ou linkar para este item:
https://ri.ufs.br/jspui/handle/riufs/646
Tipo de Documento: | Artigo |
Título: | Anti-inflammatory and redox-protective activities of citronellal |
Autor(es): | Melo, Mônica Santos de Guimarães, Adriana Gibara Santana, Michele Fraga de Barreto, Rosana de Souza Siqueira Lima, Amanda do Carmo Bion de Dias, Antônio Santos Santos, Márcio Roberto Viana dos Onofre, Alexandre Sherlley Casimiro Quintans, Jullyana de Souza Siqueira Sousa, Damião Pergentino de Almeida, Jackson Roberto Guedes da Silva Estevam, Charles dos Santos Araujo, Brancilene Santos de Quintans-Júnior, Lucindo José |
Data do documento: | Dez-2011 |
Abstract: | The anti-inflammatory and redox protective effects of the citronellal (CT) were evaluated using in vivo and in vitro tests. Intraperitoneal (i.p.) administration of CT (50, 100, and 200 mg/kg) inhibited (p < 0.05) the carrageenan-induced leukocyte migration to the peritoneal cavity. Additionally, the carrageenan- and arachidonic acid-induced rat hind paw edema was significantly inhibited (p < 0.05) by i.p. administration of 100 and 200 mg/kg of the compound. When the redox activity was evaluated, CT (200 mg/kg) significantly reduced hepatic lipoperoxidation (p < 0.001), as well as oxidation of plasmatic (p < 0.05) and hepatic (p < 0.01) proteins. The results of the present study support the hypothesis that CT possesses anti-inflammatory and redox protective activities. It is suggested that its effects are associated with the inhibition of the enzymes in the arachidonic acid pathway, which prevent cell migration by inhibiting leukotriene production, edema formation and the increase of reactive oxygen species in tissues. Therefore, CT is of potential benefit to manage inflammatory disorders and correlated damages caused by oxidant agents. |
Palavras-chave: | Monoterpenos Citronela Anti-inflamatório |
ISSN: | 0716-9760 |
Instituição/Editora: | Sociedad de Biología de Chile |
Citação: | MELO, M. S. et al. Anti-inflammatory and redox-protective activities of citronellal. Biological Research, Santiago, v. 44, n. 4, p. 363-368, 2011. Disponível em: <http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000400008&lng=es&nrm=iso>. Acesso em: 17 jul. 2013. |
Licença: | © 2013 Sociedad de Biología de Chile |
URI: | https://ri.ufs.br/handle/riufs/646 |
Aparece nas coleções: | DESL - Artigos de periódicos DFS - Artigos de periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Anti-inflammatoryActivitiesCitronellal.pdf | 289,96 kB | Adobe PDF | ![]() Visualizar/Abrir |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.