Neuropatia periférica associada a quimioterapia em crianças com neoplasia linfohematopoiética

Abstract

Objective: Characterize atypical clinical and electrophysiological manifestations of children with post-chemotherapy peripheral neuropathy vincristine admitted to an oncology service. Method: Retrospective study of a series of cases of patients with peripheral neuropathy treated in the period from 2005 to 2015. Results: They were evaluated six children with CIPN. Ages ranged from 3 to 14 years, 83.3% male. The mean time to onset of symptoms post- chemotherapy was 64.5 days. Neoplasms associated with peripheral neuropathy above were acute lymphocytic leukemia and non-Hodgkin's lymphoma. Impairment of ambulation occurred in 66.7% of patients, due to loss of muscle strength in the lower limbs. Neuropathic pain was observed in only 16.7% of patients, used anticonvulsant drugs as a treatment option. Conclusion: The chemotherapy-induced neuropathy in children is an important side effect that usually causes neuropathic pain is difficult to control and motor losses that may even prevent ambulation.