Síndrome nefrótica idiopática: evolução clínica de crianças acompanhadas no Ambulatório de Nefrologia Pediátrica do HU-UFS

Abstract

Introduction: idiopathic nephrotic syndrome (INS) is a glomerular disease which is characterized mainly by massive proteinuria (≥ 50 mg / kg / day or ≥ 40 mg/m2/hora) and hypoalbuminemia (< 2.5 g/dL). Being more common in boys than girls at a ratio of 1.6:. 1 is responsible for considerable morbidity and mortality in children, although rare; and the prognosis correlated with the spectrum of responsiveness to steroid therapy. Objectives: To analyze the clinical - demographic profile of children with SNI, response to therapy and clinical outcome to the treatment. Methods: Descriptive, retrospective study in 56 patients with SNI followed at a pediatric nephrology at the University Hospital of the Federal University of Sergipe (ANEP-HU/UFS) in Aracaju - Sergipe, between January 2010 and December 2013 The eligible for the study patients had prior registration in the unit, documented diagnosis of SNI at least 02 ambulatory consultations, made use of corticosteroids and age ≤ 18 years at diagnosis. Data were obtained by review of medical records and information confronted by absolute frequencies. Results: The predominant male (59%), aged 2-6yrs at diagnosis (57%) and origin (55%) coming from the interior of the state of Sergipe. It was noted that 88% showed sensitivity to corticosteroids at the start of treatment and 12% resistance behavior as a response early in treatment, with 20% requiring renal biopsy to find out the histopathological pattern and define the most appropriate treatment. Of these 82% used immunosuppressant after biopsy. Conclusion: SNI manifests more frequently in male children, preschool age and from the interior of Sergipe, and are most sensitive to corticosteroid therapy, and when resistant feature histopathological pattern of GEFs.