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https://ri.ufs.br/jspui/handle/riufs/23356| Document Type: | Artigo |
| Title: | Leishmanicidal activity of carvacrol-rich essential oil from Lippia sidoides Cham |
| Authors: | Farias Junior, Paulo A. Rios, Marcos Cardoso Moura, Tauanny A. Almeida, Roque Pacheco de Alves, Pericles Barreto Blank, Arie Fitzgerald Fernandes, Roberta Pereira Miranda Scher, Ricardo |
| Issue Date: | 2012 |
| Resumo : | Leishamaniasis is a disease that aff ects more than 2 million people worldwide, whose causative agent is Leishmania spp. The current therapy for leishmaniasis is far from satisfactory. All available drugs, including pentavalent antimony, require parenteral administration and are potentially toxic. Moreover, an increase in clinical resistance to these drugs has been reported. In this scenario, plant essential oils used traditionally in folk medicine are emerging as alternative sources for chemotherapeutic compounds. In this study, in vitro leishmanicidal eff ects of a thymol- and a carvacrol-rich essential oil from leaves of Lippia sidoides Cham. were investigated. The essential oils were extracted and their constituents were characterized by gas chromatography coupled to mass spectrometry (GC/MS). Both essential oils showed signifi cant activity against promastigote forms of Leishmania chagasi. However, we found that carvacrol-rich essential oil was more eff ective, with IC50/72 h of 54.8 μg/mL compared to 74.1 μg/mL for thymol-rich oil. Carvacrol also showed lower IC50 than thymol. Our data suggest that L. sidoides essential oils are indeed promising sources of leishmanicidal compounds. |
| Keywords: | Carvacrol P-cymene Essential oil composition Leishmania chagasi Lippia ssp Thymol Verbenaceae |
| ISSN: | 0716-9760 |
| Is part of: | Biological Research |
| Language: | eng |
| Publisher / Institution : | Sociedad de Biología de Chile |
| Citation: | FARIAS JUNIOR, P. A. et al. Leishmanicidal activity of carvacrol-rich essential oil from Lippia sidoides Cham. Biological Research, Santiago, v. 45, n. 4, p. 399-402, 2012. Disponível em: https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000400012&lng=en&nrm=iso&tlng=en. Acesso em: 6 out. 2025. |
| License: | Creative Commons Atribuição-NãoComercial 4.0 Internacional (CC BY-NC 4.0) |
| URI: | https://ri.ufs.br/jspui/handle/riufs/23356 |
| Appears in Collections: | DEA - Artigos de periódicos DFS - Artigos de periódicos DME - Artigos de periódicos DMO - Artigos de periódicos DQI - Artigos de periódicos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| LeishmanialActivityCarvacrolRichEssentialOil.pdf | 337,29 kB | Adobe PDF |  View/Open |
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