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Document Type:	Artigo
Title:	Leishmania infantum Induces the release of sTREM-1 in visceral leishmaniasis
Authors:	Bomfim, Lays Gisele Santos Magalhães, Lucas Sousa Santos Filho, Marcello Augusto Anchieta Peres, Nalu Teixeira de Aguiar Corrêa, Cristiane Bani Tanajura, Diego Moura Silva, Angela M. Lipscomb, Michael W. Borges, Valéria de Matos Jesus, Amélia Maria Ribeiro de Almeida, Roque Pacheco de Moura, Tatiana Rodrigues de
Issue Date:	Nov-2017
Resumo :	Visceral leishmaniasis (VL) is a systemic transmissible disease that remains to be a major global health problem. The inflammatory response during VL is characterized by the release of several cytokines and other pro-inflammatory mediators. Triggering Receptor Expressed on Myeloid Cells (TREM) are a group of evolutionarily conserved membrane-bound surface receptors expressed on neutrophils and monocytes. Engagement of TREM-1 directs intracellular signaling events that drive cytokine production, degranulation, and phagocytosis. In certain inflammatory-associated diseases, TREM-1 can also be found as a soluble form (sTREM-1), which can negatively regulate TREM-1 receptor signaling. In these studies, we now find that high levels of circulating sTREM-1 correlate directly with VL disease severity. In particular, high levels of sTREM-1 were observed in non-survivor VL patients. Furthermore, these levels of sTREM-1 positively correlated with liver size and negatively correlated with leukocyte counts and hemoglobin concentration. Moreover, we found that neutrophils exposure in vitro to Leishmania infantum modulates TREM-1, DAP12, and IL-8 gene expression, while also increasing release of sTREM-1. Finally, results revealed that higher sTREM-1 levels are associated with increasing parasite ratio. Taken together, these studies suggest that L. infantum may modulate TREM-1 in neutrophils and high levels of this molecule is associated with severe VL.
Keywords:	Visceral leishmaniasis Leishmania infantum Neutrophils STREM-1 TREM-1
ISSN:	1664-302X
Is part of:	Frontiers in Microbiology
Language:	eng
Publisher / Institution :	Frontiers Media S. A.
Citation:	BOMFIM, L. G. S. et al. Leishmania infantum Induces the release of sTREM-1 in visceral leishmaniasis. Frontiers in Microbiology, Lausanne, v. 8, n. 2265, nov. 2017. DOI: https://doi.org/10.3389/fmicb.2017.02265. Disponível em: https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2017.02265/full. Acesso em: 26 ago. 2026.
License:	Creative Commons Atribuição 4.0 Internacional (CC BY 4.0)
Identifier:	https://doi.org/10.3389/fmicb.2017.02265
URI:	https://ri.ufs.br/jspui/handle/riufs/25900
Appears in Collections:	DME - Artigos de periódicos

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