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https://ri.ufs.br/jspui/handle/riufs/26115| Tipo de Documento: | Artigo |
| Título: | Adverse drug reactions in high-risk pregnant women: a prospective study |
| Autor(es): | Oliveira Filho, Alfredo Dias de Vieira, Antonio Emanuel Soares Silva, Roberta Cruz da Neves, Sabrina Joany Felizardo Gama, Thiago Antonio Barros Lima, Ryane Vieira Oliveira, Wlisses Ramon Dias, Júlia Maria de Gonçalves |
| Data do documento: | 2017 |
| Resumo: | Background: Because pregnant women are often excluded from clinical trials, there is still very limited information about the risk and safety of prescription drugs during pregnancy. Objective: We aimed to determine the prevalence of Adverse Drug Reactions (ADRs) in high-risk pregnant women after hospital admission. A prospective study was carried out in a teaching maternity hospital in Brazil during six months. Causality of ADRs was assessed through the Naranjo Algorithm and Korean Algorithm for ADR Causality Assessment. Severity of ADRs was assessed using Hartwig’s Severity Assessment Scale. Results: The prevalence of ADRs among the 294 inpatients studied was 8.8%. The mean age was 27.14 (±7.5) y.o. Patient’s age was related to the presence of ADRs, while the manifestation of these events was not associated with any adverse pregnancy outcome. 75.9% of the ADRs reported in the study were of mild severity and 24.1% were of moderate severity. No ADR was caused by drug-drug interaction; however, a significant increase in blood pressure was observed in all patients using concurrent methyldopa and ferrous sulfate. Conclusion: Overall, ADRs were not common events among high-risk pregnant women and no adverse pregnancy outcomes following these events were observed. |
| Palavras-chave: | Adverse drug reactions High-risk pregnancy Prevalence Maternal age Methyldopa Ferrous sulfate Drug-drug interactions |
| ISSN: | 2213-7475 |
| Parte de : | Saudi Pharmaceutical Journal |
| Idioma: | eng |
| Instituição/Editora: | Elsevier |
| Citação: | OLIVEIRA FILHO, A. D. et al. Adverse drug reactions in high-risk pregnant women: a prospective study. Saudi Pharmaceutical Journal, Amsterdam, v. 25, n. 7, p. 1073–1077, 2017. DOI: http://dx.doi.org/10.1016/j.jsps.2017.01.005. Disponível em: https://www.sciencedirect.com/science/article/pii/S1319016417300191?via%3Dihub. Acesso em: 15 set. 2026. |
| Licença: | Creative Commons Atribuição-Não Comercial-Sem Derivações 4.0 Internacional (CC BY-NC-ND 4.0) |
| Identificador: | http://dx.doi.org/10.1016/j.jsps.2017.01.005 |
| URI: | https://ri.ufs.br/jspui/handle/riufs/26115 |
| Aparece nas coleções: | DME - Artigos de periódicos |
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| AdverseDrugREactionHighRiskPregnantWomen.pdf | 395,04 kB | Adobe PDF |  Visualizar/Abrir |
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